The Entourage Effect is a phrase coined and discovered in 1999 by Raphael Mechoulam, a decorated Israeli scientist who has made studying medical marijuana his life’s mission. Let’s start from the beginning: in 1963, he was the first scientist to discover the structure of and isolate cannabidiol (CBD) from the whole marijuana flower. Shortly after, he and his team were able to isolate delta-9 tetrahydrocannabinol (THC). And they kept going, isolating the various compounds of cannabis to study each one individually. From cannabigerol, to cannabichromene, to cannabicyclol, to cannabielsoin, to cannabitriol … the list goes on and on. Incredibly, Mechoulam and his team have discovered over 480 unique natural compounds within the cannabis plant.
Even though CBD has received a sizeable boost in public awareness because of its medicinal value and lack of psychoactive effects, what Raphael Mechoulam discovered after 40+ years of research is that all of the compounds of cannabis work most effectively together, rather than when individually isolated. In particular, research has shown that THC actually enhances CBD’s therapeutic effects and vice versa. Amazingly, scientists have found that CBD enhances THC’s anti-cancer and painkilling abilities while also decreasing THC’s psychoactive effects.